@TheRealBuilder

This solves a huge problem for me. Ive wondered how to measure the effect of certain things in my life (waking up early, drinking coffee, etc) to better understand the effects. Problem is how to determine the effects of interactions efficiently lol. Would take too much time.

@khaduopha2640

How do N-of-1 trials account for long term variations? Like maybe a treatment have some unknown long term side-effects that "contaminate" the effects observed during later rounds of placebo. We could take average over large population because it's reasonable to assume that one person is unrelated to another but it's probably not reasonable to assume later treatment rounds are independent from earlier rounds.