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1. Story Board
2. Hand draw all the key frames for your characters. (Block out or use simple forms to get the movement down first?)
3. Trace all those frames in anime studios and add fill in frames where needed.All those frames go in a switch layer.
4. Tween and squash to make it look better.
5.Draw background.
6. Add shadows to the characters to blend with back ground.
7. Camera movement and hit impact zoom.
8. Other effects

There are other ways to do it. Just trying to show what my process it kinda like.
The characters are Justin and Kuzai from 16bit TV.
Music is a remix done by Hellbound dochi